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Wake-promoting drugs are frequently used to treat excessive daytime sleepiness (EDS). Modafinil and armodafinil (such as Waklert 150) are first-line treatments for narcolepsy, obstructive sleep apnea, and shift-work sleep disorder that enhance alertness. Additional choices include amphetamines or methylphenidate, as well as solriamfetol (Sunosi). In certain situations, sodium oxybate formulations and pitolisant (Wakix) may also be beneficial. Before beginning any therapy, always get medical advice.